Drug Delivery & Targeting (Track)

Formulation and Evaluation of Mucoadhesive Buccal Patches of Methotrexate

Bhanja Satyabrata
Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore(k), Orissa,india

Abstract:
The goal of present investigation was to design and evaluate, Mucoadhesive bilayered buccal devices comprising of a drug containing Mucoadhesive layer and drug free backing membrane. Bilaminated patches composed of mixture of drug (Methotrexate) and sodium alginate either alone or in combination with Sodium-Carboxy Methyl Cellulose, Polyvinyl Pyrollidine, Carbopol 934 and backing membrane (ethyl cellulose).  The patches were fabricated by solvent casting technique and evaluated for film weight uniformity, thickness, swelling index, surface pH, Mucoadhesive strength, Mucoadhesive time, folding endurance, In-vitro and Ex-vivo drug release. A combination of sodium alginate with Carbopol 934 and glycerol as plasticizer, gave promising result. The optimized patches exhibited an In-vitro drugrelease of 82% through cellophane membrane and 70.78% through buccal mucosa in 8hrs with satisfactory Mucoadhesive strength and Mucoadhesive time. The in-vitro drug release kinetic through cellophane membrane fits Higuchi, while ex-vivo through Buccal mucosa, it followed zero-order kinetics. The Ex-vivo data also fitted to Korsemeyer-Peppas equation which characterizes the release mechanism as non Fickinian, which means that the drug release is not depends upon the concentration gradients.

Keywords:- Anticancer, Methotrexate, Mucoadhesive buccal patches, folding endurance, swelling index, in-vitro and ex-vivo drug release